Iran launched its heaviest missile barrage yet, firing 25-30 projectiles that directly struck Soroka Hospital in Beersheba and multiple locations across Tel Aviv, Ramat Gan, and Holon. The hospital attack represented the first direct hit on a major Israeli medical facility, leaving 6 critically injured and over 200 total casualties. Iranian missiles used new cluster warhead technology that dispersed multiple bombs over wide areas. Defense Minister Katz escalated rhetoric by explicitly calling for Khamenei's assassination, comparing him to Hitler. Netanyahu publicly rebuked these statements as "harmful remarks not reflecting government position." Iran launched a second wave of 15 missiles toward northern Israel hours later, mostly intercepted. Israeli forces retaliated by striking Iran's Arak nuclear reactor for the first time. The White House announced Trump would decide within two weeks whether to join Israeli strikes, disappointing Israeli officials who expected quicker American involvement. Direct diplomatic conversations between US envoy Witkoff and Iranian Foreign Minister Araghchi were revealed for the first time since the war began.